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dr. T.S. de Windt

Aandachtsgebieden

  • Heup
  • Knie
  • Sportorthopedie
Opleiding

2014 – 2021
Opleiding tot orthopedisch chirurg regio Midden-West (Diakonessenhuis Utrecht, OLVG Amsterdam, UMC Utrecht en St. Antonius Utrecht). 

2015
Promotie Cum Laude aan de faculteit Geneeskunde, Universiteit Utrecht.
Proefschrift: "IMPACT on cartilage repair of the knee: patient profiling and single-stage regeneration". Promotoren Prof. dr. W.J.A. Dhert, Prof. Dr. D.B.F. Saris.

2005 - 2012
Geneeskunde Universiteit Utrecht

2004-2005
Biomedische Wetenschappen Universiteit Utrecht

1998-2004
VWO, Peter Stuyvesant College, Curaçao.

Werkervaring

2023 – heden
Chef de Clinique, Orthopedisch chirurg, OCON Orthopedische kliniek. 

2021 – 2022
(Revision) arthroplasty fellow bij dr. Gijs van Hellemondt, Sint Maartenskliniek Nijmegem

2012 – 2014
Arts-onderzoeker, Alexandre Suerman MD/PhD excellent programma, afdeling Orthopadie UMC Utrecht.

Publicaties
De Windt TS, Van Laarhoven SN, Van Hellemondt GG. Bicruciate-Retaining Total Knee Arthroplasty: State of the Art for the Younger and Active Population? A Systematic Review and Future Prospective. Applied Sciences. 2022; 12(21):10721. https://doi.org/10.3390/app122110721
Korpershoek JV, Rikkers M, de Windt TS, Tryfonidou MA, Saris DBF, Vonk LA. Selection of Highly Proliferative and Multipotent Meniscus Progenitors through Differential Adhesion to Fibronectin: A Novel Approach in Meniscus Tissue Engineering. Int J Mol Sci. 2021 Aug 10;22(16):8614
Hopman SR, de Windt TS, van Erp JHJ, Bekkers, JEJ, de Gast A. Uncemented total hip arthroplasty; increased risk of early periprosthetic fracture requiring revision surgery in elderly females. J Orthop. 2021 Apr 2;(25):40-44
Saris TFF, de Windt TS, Kester EC, Vonk LA, Custers RJH, Saris DBF. Five-Year Outcome of 1-Stage Cell-Based Cartilage Repair Using Recycled Autologous Chondrons and Allogenic Mesenchymal Stromal Cells: A First-in-Human Clinical Trial. Am J Sports Med. 2021 Mar;49(4):941-947
Korpershoek, JV, Kester EC, Creemers LB, de Windt TS, Kip MMA, Saris DBF, Custers RJH. Efficacy of one-stage cartilage repair using allogeneic mesenchymal stromal cells and autologous chondron transplantation (IMPACT) compared to nonsurgical treatment for focal articular cartilage lesions of the knee: study protocol for a crossover randomized controlled trial. Trials. 2020 Oct 9;21(1):842 
Korpershoek, JV, de Windt TS, Vonk LA, Kruch AJ, Saris DB, Does Anterior Cruciate Ligament Reconstruction Protect the Meniscus and Its Repair? A Systematic Review. Orthop J Sports Med. 2020 Jul 28;8(7):232
Korpershoek, JV, Vonk LA, de Windt TS, Admiraal J, Kester EC, van Egmond N, Saris DB, Custers RJ. Intra-articular injection with Autologous Conditioned Plasma does not lead to a clinically relevant improvement of knee osteoarthritis: a prospective case series of 140 patients with 1-year follow-up. Acta Orthop. 2020 Jul 23;1-7
de Windt TS, Niemansburg SL, Vonk LA, van Delden JM, Roes KCB, Dhert WJA,
Saris DBF, Bredenoord AL. Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials. Osteoarthritis Cartilage. 2019 Jan;27(1):34-40
Saris DB, de Windt TS, Vonk LA, Krych AJ, Terzic A. Regenerative musculoskeletal care: ensuring practice implementation. Clin Pharmacol Ther 2018 Jan;103(1):50-53
de Windt TS, Vonk LA, Slaper-Cortenbach ICM, Nizak R, van Rijen MHP, Saris DB. Allogeneic mscs and recycled autologous chondrons mixed in a one-stage cartilage cell transplantion: a first-in-man trial in 35 patients. Stem Cells. 2017 Aug;35(8):1984-1993
Korpershoek, J.V, de Windt T.S, Hagmeijer H.G, Vonk L.A, Saris D.B. Cell-based meniscus repair: At the brink of clinical translation? A systematic review of preclinical studies. Orthop J Sports Med. 2017 Feb 21;5(2)
de Windt TS, Vonk LA, Slaper-Cortenbach IC, van den Broek MP, Nizak R, van Rijen MH, de Weger RA, Dhert WJ, Saris DB. Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons. Stem Cells 2017 Jan;35(1):256-264
de Windt TS, Sorel JC, IJzerman MJ, Saris DB. Can we predict the health economic value of single stage cartilage repair. Early health economic modelling of single-stage cartilage repair. Guiding implementation of technologies in regenerative medicine. J. Tissue Eng Regen Med. 2016 Oct;11(10):2950-2959
Boot W, Moojen DJ, Visser E, Lehr MA, de Windt TS, van Hellemondt G, Geurts J, Tulp NJ, Schreurs WB, Burger BJ, Dhert WJ, Gawlitta D, Vogely Ch H. Missed low-grade infection in suspected aseptic loosening has no mid to long-term consequences on the survival of total hip arthroplasty. Acta Ortop. 2015,6:678-73
de Windt TS, Saris DB, Slaper-Cortenbach IC, van Rijen MH, Gawlitta D, L.B. Creemers, R.A. de Weger, Dhert WJ, Vonk LA. Direct cell-cell contact with chondrocytes is a key mechanism in multipotent mesenchymal stromal cell-mediated chondrogenesis. Tissue Eng Part A. 2015,19-20:2536-47
Vonk LA, de Windt TS, Slaper-Cortenbach IC, Saris DB. Autologous, allogeneic, IPS or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review. Stem Cell Res Ther. 2015,May;15;6(1):94
de Windt TS, Vonk LA, Buskermolen J, Visser J, Karperien M, Bleys RL, Dhert Wj, Saris DB. Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study. Osteoarthritis cartilage. 2014,Jan;23(1):143-502014 Sep 18 
Vonk LA, de Windt TS, Kragten AH, Beekhuizen M, Mastbergen SC, Dhert WJ, Lafeber PJ, Creemers LB, Saris DB. Enhanced cell-induced articular cartilage repair regeneration by chondrons: the influence of joint damage and harvest site. Osteoarthritis cartilage. 2014 Nov;22(11):1910-7
Stenberg J, de Windt TS, Synnergren J, van der Lee J, Saris DB, Peterson L, Brittber M, Lindahl A. Clinical outcome three years after autologous chondrocyte implantation does not correlate with the expression of a predefined gene marker set in chondrocytes prior to implantation but is associated with critical signaling pathways. Orthop J Sports Med. 2014 Sep 24;2(9):232
de Windt TS, Hendriks JA, Zhao X, Vonk LA, Creemers LB, Dhert WJ, Randolph MA, Saris DB. Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how? Stem Cells Transl Med. 2014 June;3(6):723-33
de Windt TS, Vonk LA, Brittberg M, Saris DB. Treatment and prevention of (early) osteoarthritis. Fact or fiction? A systematic review. Cartilage 2013 Jul;4:5S-12S
de Windt TS, Welsch GH, Britberg M, Vonk LA, Marlovits S, Trattnig S, Saris DB. Is MRI reliable in predicting clinical outcome after articular cartilage repair of the knee? A systematic review and meta-analysis. Am J Sports Med 2013 Jul;41:1695-702
de Windt TS, Concaro S, Lindahl A, Saris DB, Brittberg M. Strategies for patient profiling in articular cartilage repair of the knee: a prospective cohort of patients treated by one experienced cartilage surgeon. KSSTA 2012 Nov;20:2225-32
Bekkers JE, de Windt TS, Brittberg M, Saris DB. Cartilage repair in soccer athletes: what evidence leads to which treatment? A critical review of the literature. Cartilage 2012 Jan;3:43S-49S
de Windt TS, Bekkers JE, Tsuchida A, Ouwerkerk J, van Casper DR, Saris DB. De technovolutie van kraakbeenregeneratie. Nederlands Tijdschrift voor Fysiotherapie. 2011 Juni;121(2):11-7.
de Windt TS, Bekkers JE, Creemers LB, Dhert WJ, Saris DB. Patient profiling in cartilage regeneration: Prognostic factors determining success of treatment for cartilage defects. Am J Sports Med. 2009 Nov;37 Suppl 1:58S-62S
Bekkers JEJ, de Windt TS, Raijmakers NJH, Dhert WJ, Saris DBF. Validation of the Knee injury and Osteoarthritis Outcome Score (KOOS) for regenerative cartilage therapy. Osteoarthritis Cartilage. 2009 Nov;17(11):1434-9.
Lidmaatschappen
  • Nederlandse Orthopaedische Vereniging (NOV)
  • Bestuurslid Dutch Knee Society (DKS)
  • Nederlandse Vereniging voor Orthopedische Traumatologie (NVOT)
  • Junior member European Knee Society (EKS)

 

Nascholing
  • Complex primary to revision total knee arthroplasty course (S&N) Watford, Engeland. (2022) 
  • Knee Revision Masterclass Sint Maartenskliniek Nijmegen, (2022)
  • Travelling fellowship Dutch and Belgian Knee society (2022)
  • Trauma-certificatie NOV incl. bijbehorende cursussen zoals AO trauma Course-Advanced Principles of Fracture Management, Davos Zwitserland (2019-2021)
  • Basiscursus Regelgeving & Organisatie voor Klinisch Onderzoekers (BROK) (2013).
Nevenactiviteiten vak-gerelateerd
2015 – heden 
Reviewer American Journal of Sports Medicine. 
2021 - heden
Onafhankelijk arts klinische studie kraakbeentherapie UMC Utrecht
2015 – 2022
Wetenschappelijk onderzoek naar kraakbeenregeneratie in de knie UMC Utrecht